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KMID : 0379520070230020165
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한국독성학회지
2007 Volume.23 No. 2 p.165 ~ p.172
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Antigastritic Effect of Carbenoxolone Disodium from Glycyrrhizae Radix
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Cho So-Yean
Lee Seung-Ho
Choi Ji-Young
Shin Eun-Myoung
Kang Sam-Sik
Jeong Jeong-Suk
Jeong Choon-Sik
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Abstract
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Glycyrrhizae Radix, the dried roots of Glycyrrhiza glabra or Glycyrrhiza uralensis Fischer(Legumino-sae), has been used as a medicine for treatment of imflammation, arthritis, respiratory ailment, skin diseases and liver problems. The purpose of this study was to examine the effect of 70% ethanol extract, 18-{beta}-glycyrrhetinic acid, glycyrol and carbenoxolone disodium from Glycyrrhizae Radix on gastritis and gastric cancer. Using these materials, we tested antibacterial activity against Helicobacter pylori, antigastritic activity for HCI-ethanol-induced gastric lesion and the pylorus ligated gastric secretion with rats, and cell viability in gastric cancer cell. 18-{beta}-glycyrrhetinic acid and carbenoxolone disodium decreased the volume of gastric secretion and acid output in pylorus ligated rats. Also, carbenoxolone disodium had a strong effect of antibacterial activity on H. pylori. In addition 18-{beta}-glycyrrhetinic acid and glycyrol reduced cell viability in human gastric cancer cells(AGS and SNU638 cell) in dose-dependent manner. The reduction of total acid output and gastric secretion as well as the anti-bacterial activity against H. pylori might account for the antigastritic effects of carbenoxolone disodium.
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KEYWORD
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18-{beta}-Glycyrrhetinic acid, Carbenoxolone disodium, Glycyrrhizae radix, Antigastritic, Gastric cancer cell, Helicobacter pylori
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